Germinal centres, rogue B cells and the genesis of immunological diseases. [ 2016 - 2020 ]

Research Grant

Researchers: Prof Robert Brink (Principal investigator)

Brief description This study will determine how the immune system is normally prevented from producing autoantibodies that target the body's own cells and how this fails in autoimmune diseases such as lupus. Targeted studies of a newly discovered "rogue" white blood cell will also provide new clues on how autoimmune diseases arise. In addition, modeling of human immunological disease in mice via CRISPR/Cas9 mutagenesis will provide valuable new insights into their causes and potential treatments.

Funding Amount $AUD 778,907.41

Funding Scheme Research Fellowships

Notes Research Fellowship