Genetic Dissection Of Stem Cell Function [ 2006 - 2009 ]

Research Grant

Researchers: A/Pr Marnie Blewitt (Principal investigator)

Brief description Adult and embryonic stem cells have enormous therapeutic potential. Haemopoietic stem cells have been the most intensely studied and widely used in a therapeutic setting, yet we have only a patchy knowledge of the genes required for their proliferation and survival. I will use classical genetic screens in the mouse to identify genes that regulate stem cell behaviour. I will analyse two existing mutant mouse strains with reduced numbers of haemopoietic stem cells, and execute a novel genetic screen utilising mice with a defect in the self-renewal of adult haemopoietic and neural stem cells, to find mice with a recovered stem cell compartment.

Funding Amount $AUD 276,750.00

Funding Scheme Early Career Fellowships

Notes Peter Doherty Biomedical ECF