Genetic approaches to understand how imbalanced cytokine signalling drives the pathogenesis of emphysema [ 2008 - 2010 ]

Research Grant

Researchers: Prof Brendan Jenkins (Principal investigator) ,  Prof Philip Bardin

Brief description Emphysema is a major component of Chronic Obstructive Pulmonary Disease (COPD), the fifth leading cause of death in Australia for which there is no effective treatment. We have discovered a specific mutation in a gene called gp130 that results in the formation of emphysema in mice. This finding allows us to understand the exact mechanisms by which this mutation causes emphysema, and therefore has the potential to uncover new strategies to design novel therapies against emphysema in humans.

Funding Amount $AUD 519,715.21

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant