Genetic approaches to osteoarthritis of the hand [ 2002 - 2003 ]

Research Grant

Researchers: Prof Graeme Jones (Principal investigator) ,  Dr Jim Stankovich ,  Dr Michele Sale ,  Prof Philip Sambrook

Brief description Osteoarthritis is the major cause of disability in elderly Australians. It is a disease of unknown aetiology that results in deterioration of the structure and function of articular cartilage. Current treatment is palliative or involves joint replacement, which is very costly. No preventive strategies are currently available. These facts have led to 2000-2010 being labelled the Bone and Joint decade. Studies have consistently indicated a higher risk of this disease in families. This study will examine for novel genes for this condition in a large family study involving over 500 subjects. Identification of susceptibility or severity genes in OA is of marked importance as it is likely to lead to a better understanding of the biochemical basis of these disorders, and translate to rational therapeutic strategies and preventative strategies in at-risk individuals in the longer term.

Funding Amount $AUD 255,500.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant