grant

Gene variants related to bone density and fracture. [ 2003 - 2005 ]

Also known as: Variants of a bone transcription factor CBFA1 that confer high bone density and protect against Colle's fracture.

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/231421]

Researchers: A/Pr Nigel Morrison (Principal investigator) ,  Prof Geoffrey Nicholson

Brief description Bone density and osteoporosis have a genetic component. Identifying genes that are involved in determining bone density may permit advances in controlling osteoporosis. We have identified a variant that is related to bone density high enough to protect individuals four fold against Colle's fracture, the common wrist fracture seen in women. In addition, some people with bone fracture at the hip, or low bone density, have mutations in this gene. The gene is a master regulator of the cells that make bone: this gives hope that it may be possible to alter bone formation through this master regulator.

Funding Amount $AUD 330,375.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

Identifiers
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