Gene therapy, stress haematopoiesis and the risk of malignancy [ 2010 - 2013 ]

Research Grant

Researchers: Prof Ian Alexander (Principal investigator) ,  A/Pr Matthew Mccormack ,  Dr Samantha Ginn ,  Prof Adrian Thrasher ,  Prof Stephen Alexander

Brief description The immense potential of gene therapy has been confirmed by the successful treatment of immune deficiencies disorders. A key issue that has emerged however is the need to avoid potentially cancer-causing genetic damage to cells undergoing repair. Some of this risk can be linked to the gene repair technology used, but we have identified and propose to investigate another potentially important mechanism involving the unusually high levels of replication imposed on cells during disease correction.

Funding Amount $AUD 617,354.91

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant