Gene identification in familial orofacial clefts by next generation sequencing of exomes and p63 regulatory elements [ 2013 - 2016 ]

Research Grant

Researchers: A/Pr Tony Roscioli (Principal investigator) ,  A/Pr Jo Huiqing Zhou ,  Dr Michael Buckley ,  Prof Edwin Kirk ,  Prof Hans Van Bokhoven
View all 6 related researchers

Brief description Cleft lip/palate (CL/P) is among the most common malformation disorders but the causes of this condition are largely unknown. We do know that gene mutations cause CL/P in some people. We have also shown that the p63 gene may influence the activity level of genes involved in CL/P by attaching to regulatory elements near these genes. Changes in as yet unidentified genes controlled by p63 are strong possibilities for the cause of CL/P. We will test these by next generation sequencing, a technique that analyses all human genes.

Funding Amount $AUD 583,617.35

Funding Scheme Project Grants

Notes Standard Project Grant