Gene - environment interactions as predictors of clinical outcome in At Risk Mental State [ 2010 - 2016 ]

Research Grant

Researchers: Prof Patrick Mcgorry (Principal investigator)

Brief description The grant aims to identify the interactive genetic, clinical and environmental determinants involved in the development, severity and outcome of schizophrenia. Translation to clinical practice will be facilitated by experimental and risk assessment bioinformatics research. This will enable the (i) identification of modifiable biological and cognitive mechanisms and (ii) construction of tools which can be used for the early prediction of transition to psychotic disorder and outcome monitoring. This study will identify the factors that translate genetic vulnerability to schizophrenia into overt illness. The key risk factors of stress and substance use and other environmental features will be studied as part of randomised clinical trials in young people with early symptoms who are at immediate risk of schizophrenia. This study forms part of a much larger international program of research focusing on clarifying how the vulnerability to schizophrenia develops and how it can ultimately be prevented

Funding Amount $AUD 1,033,620.07

Funding Scheme NHMRC Strategic Awards

Notes Aust/EU Collaborative Research Grant