Gamma-Secretase inhibitors as novel pharmacological agents to target stroke-induced brain injury [ 2011 - 2013 ]

Research Grant

Researchers: A/Pr Thiruma Arumugam (Principal investigator) ,  Dr Bradley Launikonis ,  Prof Christopher Sobey

Brief description Stroke is the world�s 2nd leading cause of death. In Australia, stroke is the leading cause of serious, long-term disability. Alarmingly, there is a looming stroke epidemic in Australia. There is an urgent need for novel therapies capable of reducing mortality and long-term disability in victims of stroke. We have recently identified gamma-secretase inhibitors (GSIs) as a potent stroke therapy. This project will investigate how GSIs protect against ischaemic stroke at the molecular level.

Funding Amount $AUD 441,511.92

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant