[Cite as http://purl.org/au-research/grants/arc/FT140100594]
Researchers Dr Michael Gantier
Brief description MicroRNAs (miRNAs) constitute a novel mechanism used by cells to regulate gene expression. However, very little is known about the mechanisms affecting miRNA accumulation. Characterisation of the kinetics of miRNA turnover is of paramount importance to establish the reliability of miRNAs as novel biomarkers. Here I propose to characterise miRNA stability in mammalian cells, investigate mechanisms of turnover and establish their importance on the regulatory function of miRNAs. Such information is critical in the future development of targeted therapeutics.
Funding Amount $751,454
Funding Scheme Future Fellowships