Research Grant
[Cite as http://purl.org/au-research/grants/arc/FT130101767]Researchers: A/Prof Pilar Blancafort (Future Fellowship )
Brief description Drugging the undruggable: Development of novel technologies to selectively regulate the expression of targets driving cancer and other diseases. Transcription factors are “undruggable” targets playing a principal role driving cancer. This project will create novel therapeutic strategies to inhibit transcription factors and other elusive targets differentially expressed in diseased cells, without affecting normal tissue. It proposes to construct engineered proteins able to bind and modify specific key genes deregulated in cancer, to correct their expression and stably reprogram the phenotype of the tumour cell in a normal-like state. It outlines the engineering of novel synthetic agents to block specific protein-protein interactions in cancer cells and to induce potent tumour cell death. This work will generate novel and selective therapeutics to treat un-curable forms of tumours.
Funding Amount $755,320
Funding Scheme ARC Future Fellowships
- ARC : FT130101767
- PURL : http://purl.org/au-research/grants/arc/FT130101767
