grant

The fungal SEC14 secretory pathway and virulence [ 2010 - 2012 ]

Also known as: How do host invading factors get released by pathogenic fungi

Funded by National Health and Medical Research Council
Managed by The University of Sydney
Managed by University of Sydney
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/632634]

Researchers: A/Pr Julianne Djordjevic (Principal investigator) ,  A/Pr Peter Williamson ,  Prof Tania Sorrell

Brief description Invasive fungal infections are a serious, escalating health issue. They cause severe disease with high death rates and are very costly to the health system. Current drugs often have suboptimal efficacy and cause side effects. New drugs are needed urgently. Many fungi, including the AIDS-related pathogen, Cryptococcus neoformans, secrete phospholipase B (Plbp) to facilitate infection. We will identify and investigate the Plbp secretion pathway as a novel anti-fungal drug target.

Funding Amount $AUD 536,304.35

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Fungal molecular pathogenesis and virulence mechanisms | Fungal opportunistic infections - Cryptococcus neoformans | Fungal secretory pathways as a drug target | Host-pathogen interaction | Immunocompromised patient-AIDS | Medical and Health Sciences | Medical Microbiology | Medical Microbiology Not Elsewhere Classified | PGP3 (Global Health) | Phospholipase B enzymes | Phospholipid homeostasis | Secretion pathways-regulation-protein trafficking-Golgi | Targeted Gene Disruption |
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