Functional suicide of selected dendritic cells by cytochrome c: an in vivo model lacking cross-presentation [ 2009 - 2011 ]

Research Grant

Researchers: Prof Andrew Lew (Principal investigator) ,  Dr Yifan Zhan ,  Prof Jose Villadangos

Brief description Certain white blood cells (dendritic cells) activate the immune system, especially its T cells. Infection of such cells elicits killer T cell responses. However not all infections infect dendritic cells. In such cases, the infectious material is eaten by dendritic cells and moved to certain areas within the cell. This process is called cross-presentation and how important it is during various diseases remains moot. We now have a model of testing this by eliminating these cross-presenting cells.

Funding Amount $AUD 597,476.39

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant