Functional effects of polymorphic variation of the aromatase (CYP19) gene on enzyme activity:relationship to disease [ 2008 - 2011 ]

Research Grant

Researchers: Dr Ian Dick (Principal investigator) ,  A/Pr Scott Wilson ,  Dr Evan Ingley ,  Prof Richard Prince

Brief description After menopause, oestrogen synthesis changes from an ovarian to an adipose source by concersion of androgens to estrogens, a process catalyzed by aromatase, the product of the CYP19 gene. We will generate mutants of the CYP19 gene that we have previously found in humans by site-directed mutagenesis and observe the effects of these mutants on aromatase function. This research will help with diagnosis and treatment of breast and other cancers and osteoporosis in humans .

Funding Amount $AUD 237,708.40

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant