grant

Function of ATRX, H3.3 and PML nuclear bodies in the regulation of telomere chromatin integrity [ 2012 - 2014 ]

Also known as: Epigenetic factors that control the formation of telomere chromatin state

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1031866]

Researchers: A/Pr Lee Wong (Principal investigator) ,  Prof Philippe Collas

Brief description The telomere is required for protecting chromosome ends. During cell division and development, telomeres lose their repeats, exposing the chromosome ends to damage. The consequences of this damage are disease, cancer, and aging. By contrast, embryonic stem cells (ES) continually renew their telomeres and do not stop growing. ES cells thereby provide a means to unravel the molecular mechanisms of indefinite telomere renewal. Here we propose a novel mechanism that operates to control continual telomere renewal in ES cells.

Funding Amount $AUD 434,652.09

Funding Scheme Project Grants

Notes Standard Project Grant

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