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Data from: Surface Presentation of Functional Peptides in Solution Determines Cell Internalization Efficiency of TAT Conjugated Nanoparticles

RMIT University, Australia
Irene Yarovsky (Aggregated by)
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ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2FANDS&rft_id=https://figshare.com/articles/Surface_Presentation_of_Functional_Peptides_in_Solution_Determines_Cell_Internalization_Efficiency_of_TAT_Conjugated_Nanoparticles/2256199&rft.title=Data from: Surface Presentation of Functional Peptides in Solution Determines Cell Internalization Efficiency of TAT Conjugated Nanoparticles&rft.identifier=9cf8a1e9fa6efe816d2919c5a64fc2b1&rft.publisher=RMIT University, Australia&rft.description=Attached file provides supplementary data for linked article. Functionalizing nanoparticles with cell-penetrating peptides is a popular choice for cellular delivery. We investigated the effects of TAT peptide concentration and arrangement in solution on functionalized nanoparticles’ efficacy for membrane permeation. We found that cell internalization correlates with the positive charge distribution achieved prior to nanoparticle encountering interactions with membrane. We identified a combination of solution based properties required to maximize the internalization efficacy of TAT-functionalized nanoparticles.&rft.creator=Irene Yarovsky&rft.date=2018&rft.relation=http://dx.doi.org/10.1021/nl5021848&rft_rights=All rights reserved&rft_rights=CC BY-NC: Attribution-Noncommercial 3.0 AU http://creativecommons.org/licenses/by-nc/3.0/au&rft_subject=Cell internalization&rft_subject=Functionalized nanoparticles&rft_subject=Gold cell-penetrating peptides molecular dynamics&rft_subject=Cell-penetrating peptides&rft_subject=Molecular dynamics&rft_subject=Biomaterials&rft_subject=ENGINEERING&rft_subject=BIOMEDICAL ENGINEERING&rft.type=dataset&rft.language=English Access the data
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Attached file provides supplementary data for linked article. Functionalizing nanoparticles with cell-penetrating peptides is a popular choice for cellular delivery. We investigated the effects of TAT peptide concentration and arrangement in solution on functionalized nanoparticles’ efficacy for membrane permeation. We found that cell internalization correlates with the positive charge distribution achieved prior to nanoparticle encountering interactions with membrane. We identified a combination of solution based properties required to maximize the internalization efficacy of TAT-functionalized nanoparticles.

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Biomedical Engineering | Biomaterials | Cell internalization | Cell-penetrating peptides | Engineering | Functionalized nanoparticles | Gold cell-penetrating peptides molecular dynamics | Molecular dynamics |

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