Fractures and bisphosphonates: reviving osteoporosis treatment uptake by identifying the genetic, material, and microstructural risk factors of atypical femur fractures. [ 2018 - 2021 ]

Research Grant

Researchers: Prof Peter Ebeling (Principal investigator) ,  A/Pr Roderick Clifton-Bligh ,  Dr Roger Zebaze ,  Prof Richard Sinnott

Brief description Atypical femoral fractures (AFF) are uncommon, but catastrophic, complications of antiresorptive osteoporosis treatments including bisphosphonates. We will identify patients at risk of AFF by determining changes in their bone structure and quality, and identifying genes that increase the risk of these fractures. In this way, cheap and effective antiresorptive treatments can be targeted to patients at the lowest risk of AFF and alternative treatments to those at highest risk.

Funding Amount $AUD 1,067,837.51

Funding Scheme Project Grants

Notes Standard Project Grant