Fibroblast Senescence as a driver of pulmonary fibrosis [ 2016 - ]

Research Grant

Researchers: Prof Darryl Knight (Principal investigator) ,  A/Pr Cecilia Prele ,  A/Pr Glen Westall ,  A/Pr Janette Burgess ,  A/Pr Steven Mutsaers
View all 6 related researchers

Brief description Idiopathic pulmonary fibrosis (IPF) has no cure. Currently we think that IPF develops like normal wound healing, but the normal “braking” mechanisms in the myofibroblasts (the cells that produce the connective tissue) don’t work, such that too much connective tissue is produced and oxygen transfer to the blood is stopped. We have identified a protein we think stops, the myofibroblasts from dying. Reducing the activation of this protein should return the myofibroblasts function to normal.

Funding Amount $845,611.00

Funding Scheme Project Grants

Notes Standard Project Grant