Fetal and genetic origins of Polycystic Ovary Syndrome (PCOS) in young women [ 2001 - 2003 ]

Research Grant

Researchers: Prof Michael Davies (Principal investigator) ,  Prof Gustaaf Dekker ,  Prof Robert Norman ,  Prof Vivienne Moore

Brief description Polycystic ovary syndrome (PCOS) is a common hormonal condition which emerges at puberty and afflicts up to 10% of women. The cause of PCOS is uncertain. Symptoms include menstrual disorders, acne, obesity, and excess body hair. PCOS is of great significance for women because of the high incidence of infertility and the high risk of other serious diseases, including diabetes mellitus and endometrial cancer. PCOS is probably the most common hormonal condition among young women. The cause of PCOS is unknown and the relationship between PCOS and the more common condition of polycystic ovaries, which often features in PCOS, is uncertain. There is evidence that genetic factors contribute to PCOS, but cannot explain certain aspects. There is also striking new evidence that abnormal growth in the womb can alter the metabolism of the baby for life, resulting in increased risks of adult disease, including diabetes and cardiovascular disease. PCOS may be another consequence of abnormal fetal growth, a suggestion that is supported by two recent studies of closely related conditions. To investigate the origins of PCOS, we propose to establish the first international study of the relationships between fetal growth, genetic factors and the presence of PCOS. In this study, we shall trace 3,260 women born in one maternity ward during 1973-75. These women, now young adults, will be invited into our study for an interview, physical examination, and a blood test. We expect 2,200 women will participate. Of this group, some 220 women with PCOS will receive further tests to investigate a range of metabolic problems. The study has the potential to illuminate the path from genetic predisposition and fetal growth, to the emergence of an important reproductive disorder with serious associated diseases in a woman s later life.

Funding Amount $AUD 449,073.44

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant