Fatty acid biosynthesis in the malaria chloroplast as a drug target [ 2002 - 2002 ]

Research Grant

Researchers: Prof Geoffrey Mcfadden (Principal investigator) ,  Prof Malcolm Mcconville

Brief description Malarial parasites contain a chloroplast similar to that of plants. We recently found genetic evidence suggesting the malaria chloroplast makes fats in the same way as plant chloroplasts. Additionally, we have found that drugs and herbicides that block plant chloroplast fat production stop growth of malaria cultures. Parasitologists had assumed that malaria was unable to make fats and would scavenge them from its human host so we have probably discovered a new metabolic pathway in these parasites. We now propose to prove that the drugs work by blocking essential, chloroplast-based fat production in parasites. This could lead to novel treatment of malaria and related parasites.

Funding Amount $AUD 131,035.45

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant