FANC gene mutations in Acute Myeloid Leukaemia biology and treatment [ 2018 - 2021 ]

Research Grant

Researchers: Prof Richard D'Andrea (Principal investigator) ,  A/Pr Ian Lewis ,  Dr Andrew Deans ,  Prof Hamish Scott ,  Prof Thomas Gonda

Brief description We have found mutations in DNA repair genes in AML patients, and associated the presence of these with increased risk of developing AML. Our hypothesis is that the presence of these mutations leads to reduced efficiency of DNA repair, and increased risk of additional mutations and leukaemic transformation. Our aim is therefore to determine the changes associated with these mutations in blood cell precursors, and to investigate the potential of targeted therapies for this group of patients.

Funding Amount $AUD 913,390.92

Funding Scheme Project Grants

Notes Standard Project Grant