Factor XII-dependent thrombosis and platelet glycoprotein Ib [ 2010 - 2012 ]

Research Grant

Researchers: A/Pr Robert Andrews (Principal investigator) ,  Prof Christopher Ward

Brief description We will determine the value of targeting the interaction between a receptor unique to platelets, glycoprotein Ib, and two factors (XI and XII) in plasma involved in blood clotting, as a novel strategy to prevent clots that lead to heart attack-stroke. Our study is at the basic research-clinical interface and has the potential to improve our understanding of both bleeding in patients with Factor XI-XII defects and prevention of dangerous levels of clotting without affecting normal vessel repair.

Funding Amount $AUD 336,767.59

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant