Extrasynaptic GABA-A receptors as novel targets for -Hydroxybutyric acid (GHB) [ 2011 - 2014 ]

Research Grant

Researchers: Prof Mary Collins Chebib (Principal investigator) ,  A/Pr Glenn Hunt ,  A/Pr Petrine Wellendorph ,  Prof Hans Bräuner-Osborne ,  Prof Iain Mcgregor

Brief description GHB (known as Fantasy) is a curious substance. It is a drug of abuse, a therapy and occurs naturally in the brain. GHB targets brain proteins including the enigmatic _GHB receptor� which participates in the therapeutic benefits of GHB. Our research will determine whether the delta-containing GABA-A receptors are the elusive "GHB receptor". Uncovering the identity of the the elusive _GHB receptor� would be a major breakthrough in terms of our understanding of the therapeutic and recreational use of GHB and its action as a brain chemical.

Funding Amount $AUD 525,946.46

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant