Expression of malaria parasite invasion associated proteins in the sporozoite novel vaccination strategy [ 2007 - 2008 ]

Research Grant

Researchers: Prof Alan Cowman (Principal investigator)

Brief description Efforts to develop vaccines against malaria still represent a substantial focus of current research activities. Antigens present in the erythrocytic pathogenic stages of the infection account for the majority of targets investigated for potential vaccines. Experimental vaccines targeting the pre-erythrocytic stages [the sporozoite injected by the mosquito, and the hepatic stage parasite) have encompassed a lesser diversity of parasite antigens]. This is the case despite the fact that experimentally induced sterile long-lasting immunity in humans has so far only been achieved through exposure to irradiated sporozoites. The acquisition and maintenance of this immunity depends on the use of invasive sporozoites and on the presence of developmentally arrested hepatic stage parasites.

Funding Amount $AUD 202,000.00

Funding Scheme NHMRC Strategic Awards

Notes Aust/EU Collaborative Research Grant