Exploiting the pharmacokinetic and pharmacodynamic properties of bile acid receptor agonists to treat liver disease [ 2015 - 2018 ]

Research Grant

Researchers: Prof Christopher Liddle (Principal investigator) ,  Dr Lionel Hebbard ,  Dr Michael Downes

Brief description We have generated preliminary data suggesting that chemicals made by the liver, called bile acids, act on fat cells to release a hormone called adiponectin. In liver disease adiponectin has favorable effects, including reducing liver inflammation and fibrosis (scarring). By using drugs that mimic the action of bile acids we expect that adiponectin production by fat cells can be increased, creating a new way to treat patients with chronic liver diseases.

Funding Amount $AUD 653,952.51

Funding Scheme Project Grants

Notes Standard Project Grant