Exploiting messenger RNA export as a novel therapeutic strategy to treat cancer [ 1/1/2021 - 12/31/2024 ]

Research Grant

Brief description Novel therapies for cancers represent an area of unmet clinical need. We have identified a new biological pathway implicated in cancer, namely selective mRNA export. Compounds inhibiting other steps of the gene expression pathway are promising therapeutic candidates for cancer, yet mRNA export inhibitors do not exist. We propose to develop first-in-class inhibitors of mRNA export that selectively target transcriptionally addicted cancers with dysregulated RNA processing.

Funding Amount $948,098

Funding Scheme Ideas Grants

Chief Investigator Dr Vihandha Wickramasinghe

Notes Ideas Grants