Exploiting and defining the immune regulatory activities of BET bromodomain inhibitors [ 2017 - 2020 ]

Research Grant

Researchers: Prof Ricky Johnstone (Principal investigator) ,  A/Pr Jake Shortt ,  A/Pr Michael Kershaw ,  A/Pr Phillip Darcy ,  Prof Joseph Trapani

Brief description Immune-based agents such as “checkpoint inhibitors” have the ability to re-awaken our own immune systems and activate previously dormant anti-tumor responses. We have discovered that small molecule inhibitors of gene regulatory proteins called bromodomain proteins act synergistically with checkpoint inhibitors in mouse cancer models. We will define the molecular and biological events underpinning this novel combination approach and assess the effects of the combination across different tumors.

Funding Amount $AUD 923,222.68

Funding Scheme Project Grants

Notes Standard Project Grant