grant

Exploiting and defining the immune regulatory activities of BET bromodomain inhibitors [ 2018 - 2021 ]

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1151409]

Brief description Immune-based agents such as “checkpoint inhibitors” have the ability to re-awaken our own immune systems and activate previously dormant anti-tumour responses. We have discovered that small molecule inhibitors of gene regulatory proteins called bromodomain proteins act synergistically with checkpoint inhibitors in mouse cancer models. I will define the molecular and biological events underpinning this novel combination approach and assess the effects of the combination across different tumours.

Funding Amount $AUD 128,224.82

Funding Scheme Postgraduate Scholarships

Notes Medical/Dental Postgraduate Scholarship

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