Exploiting the cross talk between Tuft cells and group 2 innate lymphoid cells for tissue homeostasis and disease [ 2018 - ]

Research Grant

Researchers: Dr Michael Buchert (Principal investigator) ,  Dr Cyril Seillet ,  Prof Richard Locksley

Brief description The project investigates the cellular cross talk within the gastric mucosa between tuft cells, a rare epithelial cell type, and tissue-resident group 2 innate lymphoid cells (ILC2). The tuft cell/ILC2 axis is driven by the two cytokines interleukin (IL)-25 and IL-13 and is required for tissue homeostasis but turns pro-tumourigenic in the context of chronic inflammation. Our investigation will dissect the underlying mechanisms using a combination of mouse models, immunology and bioinformatics.

Funding Amount $831,162.00

Funding Scheme Project Grants

Notes Standard Project Grant