grant

Expansion of TGF-beta-Smad signaling network and intrinsic epithelial-mesenchymal-endothelial transition [ 2007 - 2010 ]

Also known as: TGF-beta signaling and tumor vascularization

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/433619]

Researchers: Dr Hong-Jian Zhu (Principal investigator)

Brief description The majority of tumor death occurs due to tumor metastasis. Both tumor growth and tumor spread require angiogenesis, which is thought to be driven by tumor but originated from host endothelial cells. Could tumor cells behave and function like endothelial cells? This application aims to detect the transition of adult epithelial cells to endothelial cells through a transient mesenchymal state. Our studies should reveal both the molecular and cellular causes of vasculogenic mimicry, thus establishing a new paradigm in understanding tumor growth and metastasis. Such novel molecular understanding will open up new anti-tumor therapeutic opportunities.

Funding Amount $AUD 557,297.18

Funding Scheme Project Grants

Notes Standard Project Grant

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