Excitatory interneurons: a sensory amplifier for pathological pain [ 2018 - 2020 ]

Research Grant

Researchers: A/Pr Brett Graham (Principal investigator) ,  A/Pr Christopher Dayas ,  Dr David Hughes ,  Prof Robert Callister

Brief description Changes to the nervous system during pathological pain remain poorly understood. This poses a barrier to new and more effective pain therapies. We have recently shown that a population of excitatory nerve cells, which express a protein called calretinin, form an amplifier network within the spinal cord that enhances pain signalling. This application will determine how calretinin-positive nerve cells contribute to pathological pain and can subsequently be targeted to provide pain relief.

Funding Amount $AUD 658,945.86

Funding Scheme Project Grants

Notes Standard Project Grant