grant

Examining the role of ASIC channels in pain through the development of subtype-specific ASIC channel modulators. [ 2008 - 2010 ]

Also known as: Developing selective tools to study the involvement of acid sensors in pain.

Funded by National Health and Medical Research Council
Managed by The University of Queensland
Managed by University of Queensland
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/511067]

Researchers: Dr Lachlan Rash (Principal investigator) ,  Prof Glenn King ,  Prof Paul Alewood

Brief description Acid sensing ion channels (ASICs) sense changes in acidity in the body. They are found throughout the body and may underlie nerve damage in stroke and some types of pain. ASICs also have many as yet unknown functions. A lack of selective tools to study ASICs is a major barrier to a complete understanding of what they do. This proposal aims to modify three animal toxins which block these receptors to make useful tools to study their function, in particular their role in sensing pain.

Funding Amount $AUD 617,256.35

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Biomedical and Clinical Sciences | Medical Microbiology | Medical Virology | Pharmacology | ligand gated ion channel function - ion channel diseases | ligand-gated ion channels | mechanisms of pain | molecular pharmacology | neuroprotective drugs to minimise neural death after stroke | pain management | sensory neurons | structure-activity relationships |
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