grant

EXAMINING THE RELATIONSHIP BETWEEN MATRIPTASE-2 AND HEMOJUVELIN, TWO ESSENTIAL REGULATORS OF IRON HOMEOSTASIS [ 2010 - 2012 ]

Also known as: The Role of Matriptase-2 and Hemojuvelin in Iron Metabolism

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/613643]

Researchers: Prof V. Nathan Subramaniam (Principal investigator) ,  Dr Daniel Wallace Prof Carlos Lopez-Otin Prof John Hooper

Brief description The control of iron levels is important in health and well being. Too little can lead to iron deficiency and anaemia, conversly too much can lead to haemochromatosis and tissue damage. We will examine the role of two proteins, matriptase-2 and hemojuvelin that when mutated cause iron deficiency or iron overload respectively. We will study how these proteins interact and work in opposite directions to control iron levels. The results will help to develop new therapeutics for iron disorders.

Funding Amount $AUD 533,541.03

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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