grant

Evolution and targeting of polysaccharide biosynthesis in Leishmania parasites [ 2009 - 2011 ]

Also known as: Novel metabolic enzyme in Leishmania parasites

Funded by National Health and Medical Research Council
Managed by The University of Melbourne
Managed by University of Melbourne
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/566644]

Researchers: Prof Malcolm Mcconville (Principal investigator) ,  Prof Spencer Williams

Brief description Leishmania are parasitic protozoa that cause devastating diseases in humans. This proposal will identify the enzymes involved in the biosynthesis of an unusual carbohydrate reserve material that accumulates in pathogenic stages of these parasites. Information on the structure and mode of action of these enzymes will be used to develop novel drugs that will be tested for anti-parasite activity.

Funding Amount $AUD 449,484.42

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Biomedical and Clinical Sciences | Dental Materials and Equipment | Dentistry | antiparasitic chemotherapy | biochemical | carbohydrate metabolism | drug target | enzyme inhibtion | enzyme structure | metabolism | microbial protozoan parasites | molecular basis of disease | parasitology |
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