Evaluating the T cell calculus [ 2007 - 2009 ]

Research Grant

Researchers: Prof Philip Hodgkin (Principal investigator) ,  Dr Frank Battye ,  Prof Alan Perelson ,  Prof Miles Davenport ,  Prof Rob De Boer

Brief description The immune system plays an important role in protecting us from infectious diseases. To do this it regulates a series of cell types that must decide upon an appropriate course. In general, this response is successful and protective. However, occasionally the cells make an inappropriate decision leading to problems. For example, allergies are an incorrect response against pollens and dust mites. Similarly, autoimmune disease such as diabetes and multiple sclerosis result from inappropriate attack upon our own tissues. Despite the clear importance of immune regulation for health, the number of different cell types involved and the complexity of their behaviour has made it difficult to predict and control the response. In this research program a new theory of immune regulation enables the reduction of the complex system to separate components that can be modelled by computer to predict the outcome. An improved predictive framework promises to have a major effect on our understanding and ability to control immune related diseases.

Funding Amount $AUD 447,210.05

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant