Essential roles of RNA polymerase II transcription and DNA damage response pathway in the maintenance of centromere chromatin assembly [ 2013 - 2015 ]

Research Grant

Researchers: A/Pr Lee Wong (Principal investigator) ,  Dr Lee H Wong

Brief description A centromere is a region of DNA typically found near the middle of a chromosome where two identical sister chromatids come in contact. It is involved in cell division as the point of attachment to the mitotic spindle. Defective centromeres can result in genome instability, infertility and development of cancers. This work involves a study into how the identity of a centromere is maintained and inherited after each cell division. This has significant implication in the understanding of cell growth and cancer development.

Funding Amount $AUD 601,224.45

Funding Scheme Project Grants

Notes Standard Project Grant