Escape from BRAF-induced human melanocyte senescence in the genesis of melanoma [ 2008 - 2010 ]

Also known as: Switching on BRAF-induced senescence in human melanocytes

Research Grant

[Cite as]

Researchers: Prof Helen Rizos (Principal investigator) ,  Prof Richard Kefford

Brief description Melanoma is the most lethal form of skin cancer and activation of the MAPK growth pathway is a crucial step in the initiation of this cancer, but alone is insufficient, as most melanocytes with active MAPK exist in a growth arrested state. The mechanisms responsible for arresting melanocytes in the presence of active MAPK will be investigated. This project will discover why some melanocytes develop into melanomas whereas most do not.

Funding Amount $AUD 601,776.01

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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