Eradication of high-risk bacterial clones using bacteriophages [ 2016 - ]

Research Grant

Researchers: Prof Jonathan Iredell (Principal investigator) ,  Dr Carola Venturini ,  Dr Nicola Petty ,  Dr Sandra Porteous Morales ,  Prof Nicholas Thomson

Brief description Nature offers remedies to the spread of dangerous antibiotic resistant bacteria in the form of predatory viruses (bacteriophages). In this project, we will define optimal mixtures of these for killing problem bacterial types, the mechanisms by which bacterial resistance develops, the best approach to identifying susceptible bacteria and to using these viruses to eradicate them, and we will test a carefully optimised bacteriophage therapy in humans colonised by the dangerous E. coli ST131 strain.

Funding Amount $685,070.00

Funding Scheme Project Grants

Notes Standard Project Grant