ER stress-Unfolded Protein Response a critical metabolic pathway for airway remodelling in asthma [ 1/1/2021 - 12/31/2023 ]

Research Grant

Brief description Airway remodelling in asthma is associated with poor clinical outcomes and is not prevented by current treatments. We have found endoplasmic reticulum stress (ERS) and associated unfolded protein response (UPR), a crucial process involve in cellular protein folding, play a key role in airway remodelling in asthma. This study will investigate whether inhibition of ERS prevents goblet cell metaplasia, mucus hypersecretion and fibrosis and can be used as a therapeutic strategy for severe asthma.

Funding Amount $789,475

Funding Scheme Ideas Grants

Chief Investigator Prof Peter Wark

Notes Ideas Grants