grant

Epimutations as germ-line defects in hereditary cancer syndromes [ 2008 - 2010 ]

Also known as: Epimutations as a cause of familial cancers

Funded by National Health and Medical Research Council
Managed by University of New South Wales
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/510350]

Researchers: Dr Megan Hitchins (Principal investigator) ,  Prof Robyn Ward

Brief description Traditionally familial cancers were thought to be caused and inherited by spelling mistakes within the genetic code of cancer prevention genes. Our group has found that a 'chemical coat' around the MLH1 gene, causing it to be switched off, can also be inherited in some cases of bowel cancer, without any mistakes within the gene's code. We will determine if this 'coat' causes other types of cancer and if this runs in families. We also hope to find out how the coat is formed and may be reversed.

Funding Amount $AUD 385,925.62

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
321015 | Disease causation | Early-onset cancers | Epigenetic inheritance | Epimutation | Familial breast cancers | Familial cancer | Familial colorectal cancers | Familial hamartomatous tumours | Hereditary cancer syndromes |
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