Epigenetic signatures of abnormal adult neurogenesis in Rett syndrome [ 2017 - 2019 ]

Research Grant

Researchers: Prof Geoffrey Faulkner (Principal investigator) ,  Dr Dhanisha Jhaveri ,  Prof Perry Bartlett ,  Prof Ryan Lister

Brief description Rett syndrome (RTT) is a severe neurodevelopmental condition arising in early childhood. In Australia, RTT affects an estimated 1/8500 females. The vast majority of RTT patients carry a single mutation in the gene MeCP2. Recent advances in genetic engineering may allow MeCP2 mutations to be corrected in patients. This study will assess whether other molecular factors are involved in the RTT phenotype in patient neurons, and whether these factors are likely to be corrected by MeCP2 gene therapy.

Funding Amount $AUD 888,996.56

Funding Scheme Project Grants

Notes Standard Project Grant