Epigenetic regulation of telomere chromatin and genome stability [ 2017 - 2019 ]

Research Grant

Researchers: A/Pr Lee Wong (Principal investigator) ,  Prof Philippe Collas

Brief description Telomeres are structures at the end of the chromosomes that impact cell replication. 15% of cancers, called ALT cancers, show telomere instability, increased DNA damage and are frequently mutated for the ATRX gene. ALT cancers have poor prognosis, due to the limited understanding of ALT cancer activation. This study aims to create a model of ALT activation to uncover the mechanisms that control ALT tumourigenesis. This could lead to potential ALT-specific diagnostic and therapeutic tools.

Funding Amount $AUD 648,239.23

Funding Scheme Project Grants

Notes Standard Project Grant