Epigenetic regulation of L1 retrotransposition in mouse models of abnormal human neurobiology [ 2013 - 2015 ]

Research Grant

Researchers: Prof Geoffrey Faulkner (Principal investigator) ,  Dr Kyle Upton ,  Dr Lucia Clemens-Daxinger

Brief description Retrotransposons are mobile genes that copy-and-paste themselves to spread in DNA. Until very recently, they were thought to only be active in sperm and egg. In our recent work, we demonstrated that they also move in the brain. In the current study, we will use cutting-edge technologies to determine how retrotransposons change the genetic makeup of neurons in neurodevelopmentally impaired mice to predict whether these mutations would also be present in human brain disorders.

Funding Amount $AUD 417,812.94

Funding Scheme Project Grants

Notes Standard Project Grant