Epigenetic mechanisms of dysregulated immune function in autoimmune and allergic disease of childhood [ 2017 - 2019 ]

Research Grant

Researchers: Prof Leonard Harrison (Principal investigator) ,  A/Pr Alicia Oshlack ,  Dr Yuxia Zhang ,  Prof Anne-Louise Ponsonby ,  Prof Jennifer Couper
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Brief description The rising incidence of autoimmune and allergic diseases is ascribed to the environment, which can modify the chemistry of DNA and how our genes work (epigenetics). We aim to identify epigenetic changes in immune cells in infants at risk for type 1 diabetes and food allergy followed from birth. This may reveal both general and disease-specific levels of epigenetic-immune dysregulation and is a foundation on which to understand potentially modifiable environment-gene interactions.

Funding Amount $AUD 463,101.37

Funding Scheme Project Grants

Notes Standard Project Grant