grant

How the environment and epigenetics affect the brain disease gene, MAPT. [ 2012 - 2012 ]


Funded by National Health and Medical Research Council
Managed by The University of New South Wales
Managed by University of New South Wales
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1021269]

Researchers: A/Pr John Kwok (Principal investigator)

Brief description Genetic variants in the microtubule associated protein Tau (MAPT) gene are major risk factors for Alzheimer’s disease and Parkinson’s disease. Environmental or lifestyle factors, such as diet and smoking, have crucial roles in changing the risk of developing these diseases. These environmental factors may exert their influence via a mechanism known as "epigenetics". This project aims to determine whether the MAPT gene is susceptible to epigenetic changes by environmental factors, and whether this process will have an impact on these diseases.

Funding Scheme Project Grants

Notes Standard Project Grant

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Subjects
Alzheimer disease | Biological Sciences | Epigenetics (Incl. Genome Methylation and Epigenomics) | Genetics | Parkinson disease | animal model | complex genetic disease | disease mechanisms | disease susceptibility | methylation | molecular genetics | neurodegenerative disorders |
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