grant

Enhancing host defence against intracellular pathogens by preventing iNOS interaction with a negative regulator, SSB-2 [ 2010 - 2012 ]

Also known as: Enhancing the immune response by disruption of the iNOS-SSB-2 interaction

Funded by National Health and Medical Research Council
Managed by The Walter and Eliza Hall Institute of Medical Research
Managed by Walter and Eliza Hall Institute
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/637348]

Researchers: A/Pr Sandra Nicholson (Principal investigator) ,  Dr Bernadette Saunders

Brief description Secretion of nitric oxide (NO) gas by immune cells is a critical defence mechanism for the killing of intracellular pathogens. Production of NO within cells is regulated by the enzyme iNOS. We propose that preventing iNOS from interacting with its natural inhibitor protein (SSB-2) would allow enhanced and prolonged iNOS expression leading to increased NO and increased killing of pathogens such as the mycobacterium tuberculosis and the Leishmania parasite.

Funding Amount $AUD 448,881.12

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

Click to explore relationships graph
Help

Related Organisations

Related People

Subjects
Immunology | Innate Immunity | Medical and Health Sciences | SPRY domains | inducible nitric oxide synthase | infectious diseases | macrophage | mycobacterial infection | protein-protein interactions | protozoan parasitic disease | regulation of immune response | signalling | tuberculosis |
Identifiers
Viewed: [[ro.stat.viewed]]
Saved to MyRDA Save to MyRDA