grant

Enhancing host defence against intracellular pathogens by preventing iNOS interaction with a negative regulator, SSB-2 [ 2010 - 2012 ]

Also known as: Enhancing the immune response by disruption of the iNOS-SSB-2 interaction

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/637348]

Researchers: A/Pr Sandra Nicholson (Principal investigator) ,  Dr Bernadette Saunders

Brief description Secretion of nitric oxide (NO) gas by immune cells is a critical defence mechanism for the killing of intracellular pathogens. Production of NO within cells is regulated by the enzyme iNOS. We propose that preventing iNOS from interacting with its natural inhibitor protein (SSB-2) would allow enhanced and prolonged iNOS expression leading to increased NO and increased killing of pathogens such as the mycobacterium tuberculosis and the Leishmania parasite.

Funding Amount $AUD 448,881.12

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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