grant

Engineered tumour-homing bacteria that safely turn up the heat on immunologically cold colorectal cancers

Also known as: Ideas Grants

Funded by National Health and Medical Research Council
Managed by South Australian Health and Medical Research Institute
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/2018793]

Funding Amount $808,254.27

Full description The most prevalent colorectal cancer subtype has a low mutational burden and does not respond well to immunotherapies. The immune agonist anti-CD40 can drive immune infiltration into this cancer subtype and can reduce tumour burden in a mouse model that faithfully recapitulates the disease, however induces severe toxicity. This project will determine if expressing CD40 agonists in probiotic bacteria can be used to reduce this toxicity and effectively suppress colorectal cancer growth.

Chief Investigator Dr Stephen Blake

Date Announced 2022-12-14T00:00:00

Sector Research Institutes

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Spatial Coverage And Location

text: SA

Subjects
Basic Science Research | Immunology | Medical and Health Sciences | Tumour Immunology | acute liver injury | biomedical and clinical sciences | cd40/ cd40l interactions | colorectal cancer treatment | immunotherapy | molecular microbiology |
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