Engendering biased signalling at the human calcium sensing receptor (CaSR) to correct pathophysiology [ 2015 - 2018 ]

Research Grant

Researchers: Dr Katie Leach (Principal investigator) ,  Prof Arthur Conigrave ,  Prof Rebecca Mason

Brief description The human calcium sensing receptor (CaSR) has been targeted therapeutically in hyperparathyroidism and osteoporosis, but current CaSR therapeutics exhibit problematic side effects or are ineffective. Thus, the current research proposal seeks to understand the specific properties of CaSR drugs required to selectively control whole body calcium and bone mineral metabolism, to identify ligands that can mediate desired therapeutic effects at the exclusion of adverse effects.

Funding Amount $AUD 633,860.01

Funding Scheme Project Grants

Notes Standard Project Grant