Endothelial dysfunction as a therapeutic target in severe malaria [ 2010 - 2013 ]

Research Grant

Researchers: A/Pr Tsin Yeo (Principal investigator) ,  Prof Nicholas Anstey (Principal investigator) ,  Dr Daniel Lampah ,  Dr Enny Kenangalem ,  Prof Arjen Dondorp
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Brief description Even with very best drugs to kill malaria parasites, over 15% of patients with severe malaria still die. Their blood vessels are clogged up by malaria parasites. We have shown that the cells lining their blood vessels can't make enough nitric oxide to keep them non-sticky and allow blood through. We want to test whether giving arginine can 1) increase nitric oxide, 2) open up the clogged blood vessels and 3) dampen down other processes that clog up blood vessels in severe malaria.

Funding Amount $AUD 842,329.95

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant