Elucidating the roles and mechanisms of activation of NLRP3 inflammasomes and developing therapeutic interventions for severe steroid-resistant asthma [ 2017 - ]

Research Grant

Researchers: Prof Philip Hansbro (Principal investigator) ,  Prof Luke O'Neill ,  Prof Matthew Cooper ,  Prof Peter Gibson

Brief description Severe asthma is a major clinical issue. There are no effective treatments because we don’t understand how it occurs. We have identified a factor called an “inflammasome” that we think causes severe asthma. We have produced a new inhibitor of this factor, and shown experimentally that it may suppress important symptoms of severe asthma. We now aim to work out precisely how this inflammasome causes severe asthma and progress our new inhibitor towards therapeutic development.

Funding Amount $961,929.00

Funding Scheme Project Grants

Notes Standard Project Grant